Hyperthermia decreases the response to vasoconstrictors in rat portal veins

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Hyperthermia decreases the response to vasoconstrictors in rat portal veins.

The rat portal vein is a useful pharmacological model to study the contractions of smooth muscle cells through both receptor-dependent and receptor-independent mechanisms. We previously showed that sepsis decreases the spontaneous and agonist-induced contractile response to angiotensin II in this model. To determine whether acidosis and hyperthermia, which occur in sepsis, might contribute to t...

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ژورنال

عنوان ژورنال: European Journal of Pharmacology

سال: 2004

ISSN: 0014-2999

DOI: 10.1016/j.ejphar.2004.04.047